Observational study of coagulation activation in early breast cancer: development of a prognostic model based on data from the real world setting.

ABSTRACT: BACKGROUND:Cancer and coagulation activation are tightly related. The extent to which factors related to both these pathologic conditions concur to patient prognosis intensely animates the inherent research areas. The study herein presented aimed to the development of a tool for the assessment and stratification of risk of death and disease recurrence in early breast cancer. METHODS:Between 2008 and 2010, two hundreds thirty-five (N: 235) patients diagnosed with stage I-IIA breast cancer were included. Data on patient demographics and clinic-pathologic features were collected in course of face-to-face interviews or actively retrieved from clinical charts. Plasma levels of plasminogen activator inhibitor type 1 (PAI-1), fragment 1 + 2 (F1 + 2), thrombin antithrombin complex (TAT), factor VI

SUBMITTER: Mandoj C 

PROVIDER: S-EPMC5956941 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature