Mesocorticolimbic Connectivity and Volumetric Alterations in DCC Mutation Carriers.

ABSTRACT: The axon guidance cue receptor DCC (deleted in colorectal cancer) plays a critical role in the organization of mesocorticolimbic pathways in rodents. To investigate whether this occurs in humans, we measured (1) anatomical connectivity between the substantia nigra/ventral tegmental area (SN/VTA) and forebrain targets, (2) striatal and cortical volumes, and (3) putatively associated traits and behaviors. To assess translatability, morphometric data were also collected in Dcc-haploinsufficient mice. The human volunteers were 20 DCC^+/- mutation carriers, 16 DCC^+/+ relatives, and 20 DCC^+/+ unrelated healthy volunteers (UHVs; 28 females). The mice were 11 Dcc^+/- and 16 wild-type C57BL/6J animals assessed during adole

SUBMITTER: Vosberg DE 

PROVIDER: S-EPMC5956985 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature