Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro.

ABSTRACT: East Coast fever (ECF) caused by Theileria parva kills cattle in East, Central and Southern Africa leading to significant economic losses. Vaccination is used as a control strategy against ECF and is presently dependent on deliberate infection with live sporozoites and simultaneous treatment with a long-acting oxytetracycline. Although effective, this method has serious limitations; the immunity is parasite strain specific and immunized cattle can become life-long asymptomatic carriers of the parasite, posing risk for the spread of the disease. In efforts to develop a subunit vaccine, the role of antibodies in the neutralization of T. parva sporozoites infection of host cells has been investigated and a circumsporozoite protein, p67, is able to induce such neutralizing antibodies. However,

SUBMITTER: Nyagwange J 

PROVIDER: S-EPMC5956992 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature