Facile synthesis of α-alkoxymethyltriphenylphosphonium iodides: new application of PPh3/I2.

ABSTRACT: An efficient one pot method for the synthesis of α-alkoxymethylphosphonium iodides is developed by using PPh3/I2 combination at room temperature. Reaction conditions are found general to synthesize wide range of structurally variant alkoxymethylphosphonium iodides in high yield (70-91%). These new functionalized phosphonium salts are further used in stereoselective synthesis of vinyl ethers as well as in carbon homologation of aldehydes.

SUBMITTER: Gondal HY 

PROVIDER: S-EPMC5957017 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature