Influence of FTO rs9939609 polymorphism on appetite, ghrelin, leptin, IL6, TNFα levels, and food intake of women with morbid obesity.

ABSTRACT:

Background

The fat mass and obesity-related (FTO) gene has a strong relationship with obesity, extreme obesity and inflammatory state, and may also be associated with food intake regulation.

Objective

The aim of the present study was to evaluate the influence of the rs9939609 single-nucleotide polymorphism of the FTO gene on appetite, ghrelin, leptin, interleukin 6 (IL6), tumor necrosis factor α (TNFα) levels and food intake of morbidly obese women.

Materials and methods

The study comprised 70 women, aged between 20 and 48 years, from Rio de Janeiro, Brazil. The participants were selected according to the body mass index between 40 and 60 kg/m². Anthropometric and biochemical data were measured during fasting. Hormones and inflammatory data we

SUBMITTER: Magno FCCM 

PROVIDER: S-EPMC5957059 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature