Medulloblastoma in the Molecular Era.

ABSTRACT: Medulloblastoma is the most common malignant brain tumor of childhood and remains a major cause of cancer related mortality in children. Significant scientific advancements have transformed the understanding of medulloblastoma, leading to the recognition of four distinct clinical and molecular subgroups, namely wingless (WNT), sonic hedgehog, group 3, and group 4. Subgroup classification combined with the recognition of subgroup specific molecular alterations has also led to major changes in risk stratification of medulloblastoma patients and these changes have begun to alter clinical trial design, in which the newly recognized subgroups are being incorporated as individualized treatment arms. Despite these recent advancements, identification of effective targeted therapies remains a chall

SUBMITTER: Miranda Kuzan-Fischer C 

PROVIDER: S-EPMC5957312 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature