Disrupted interhemispheric functional connectivity in chronic insomnia disorder: a resting-state fMRI study.

ABSTRACT:

Background

Abnormalities in both cerebral structure and intrinsic activity have been increasingly reported in patients with chronic insomnia disorder (CID). However, the inter-hemispheric integration function in CID is still not well understood. Functional homotopy reflects an essential aspect of the intrinsic functional architecture involved in interhemispheric coordination.

Methods

In this study, voxel-mirrored homotopic connectivity (VMHC) was used to analyze the patterns of interhemispheric intrinsic functional connectivity in patients with CID (n=29).

Results

Reduced homotopic connectivity was observed in the middle occipital/posterior middle temporal gyrus in CID patients relative to control subjects. Further analyses demonstrated different insomnia-related hete

SUBMITTER: Zhou F 

PROVIDER: S-EPMC5957476 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature