18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal.

ABSTRACT:

Background

On target 18F-Flortaucipir (FTP) binding of Alzheimer's disease tau aggregates and off-target binding of melanocytes have been demonstrated with autoradiography.

Objective

We aimed to investigate the hypothesis that if binding in choroid plexus (CP) is due to melanocytes, the signal would be elevated in Black/African American (B/AA) compared to White (W) participants. In addition, we examined whether CP signal affects measurements in adjacent regions, and whether correcting for spill-in effects has an influence on associations between hippocampus (HC) FTP and amyloid or cognition.

Methods

FTP race differences in 147 Harvard Aging Brain Study participants (23 B/AA, 124W) were examined in CP, HC, HC covaried for CP, amygdala, inferior temporal gyrus, entorhin

SUBMITTER: Lee CM 

PROVIDER: S-EPMC5957532 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature