Auxin decreases chromatin accessibility through the TIR1/AFBs auxin signaling pathway in proliferative cells.

ABSTRACT: Chromatin accessibility is closely associated with chromatin functions such as gene expression, DNA replication, and maintenance of DNA integrity. However, the relationship between chromatin accessibility and plant hormone signaling has remained elusive. Here, based on the correlation between chromatin accessibility and DNA damage, we used the sensitivity to DNA double strand breaks (DSBs) as an indicator of chromatin accessibility and demonstrated that auxin regulates chromatin accessibility through the TIR1/AFBs signaling pathway in proliferative cells. Treatment of proliferating plant cells with an inhibitor of the TIR1/AFBs auxin signaling pathway, PEO-IAA, caused chromatin loosening, indicating that auxin signaling functions to decrease chromatin accessibility. In addition, a transcri

SUBMITTER: Hasegawa J 

PROVIDER: S-EPMC5958073 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature