Assessing the Feasibility of Neutralizing Osteopontin with Various Therapeutic Antibody Modalities.

ABSTRACT: Osteopontin is a secreted glycophosphoprotein that is highly implicated in many physiological and pathological processes such as biomineralization, cell-mediated immunity, inflammation, fibrosis, cell survival, tumorigenesis and metastasis. Antibodies against osteopontin have been actively pursued as potential therapeutics for various diseases by pharmaceutical companies and academic laboratories. Many studies have demonstrated the efficacy of osteopontin inhibition in a variety of preclinical models of diseases such as rheumatoid arthritis, cancer, nonalcoholic steatohepatitis, but clinical utility has not yet been demonstrated. To evaluate the feasibility of osteopontin neutralization with antibodies in a clinical setting, we measured its physiological turnover rate in humans, a sensitiv

SUBMITTER: Farrokhi V 

PROVIDER: S-EPMC5958109 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature