Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures.

ABSTRACT: Although the link between sleep disturbances and dopamine (DA)-related neurological and neuropsychiatric disorders is well established, the impact of sleep alterations on neuronal activity of midbrain DA-ergic structures is currently unknown. Here, using wildtype C57Bl mice, we investigated the circadian- and sleep-related modulation of electrical neuronal activity in midbrain ventral-tegmental-area (VTA) and substantia nigra (SN). We found no significant circadian modulation of activity in SN while VTA displayed a low amplitude but significant circadian modulation with increased firing rates during the active phase. Combining neural activity recordings with electroencephalogram (EEG) recordings revealed a strong vigilance state dependent modulation of neuronal activity with increased acti

SUBMITTER: Fifel K 

PROVIDER: S-EPMC5958140 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature