Fabrication of Circular Obelisk-Type Multilayer Microneedles Using Micro-Milling and Spray Deposition.

ABSTRACT: In this study we present the fabrication of multilayer microneedles with circular obelisk and beveled-circular obelisk geometries, which have potential applications in implantable drug delivery devices. Micro-milling was adopted as an environmental-friendly and cost-effective way to fabricate primary metal microneedle masters. Polylactic acid (PLA) microneedles with sharp tips were then obtained by micromolding followed by oxygen plasma etching and used for preparing polydimethylsiloxane (PDMS) microneedle molds. A spray deposition process was employed for microneedle fabrication to facilitate the formation of multilayer microneedles while helping in maintenance of drug stability. Multilayer microneedles were successfully formed by sequential spraying of poly(lactic-co-glycolic acid) (PLGA

SUBMITTER: Kim MJ 

PROVIDER: S-EPMC5958193 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature