The Genomic Basis of Intrinsic and Acquired Antibiotic Resistance in the Genus Serratia.

ABSTRACT: Serratia marcescens, a member of the Enterobacteriaceae family, was long thought to be a non-pathogenic bacterium prevalent in environmental habitats. Together with other members of this genus, it has emerged in recent years as an opportunistic nosocomial pathogen causing various types of infections. One important feature of pathogens belonging to this genus is their intrinsic and acquired resistance to a variety of antibiotic families, including β-lactam, aminoglycosides, quinolones and polypeptide antibiotics. The aim of this study was to elucidate which genes participate in the intrinsic and acquired antibiotic resistance of this genus in order to determine the Serratia genus resistome. We performed phylogenomic and comparative genomic analyses using 32 Serratia spp. genomes deposited i

SUBMITTER: Sandner-Miranda L 

PROVIDER: S-EPMC5958200 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature