FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate.

ABSTRACT: Fibroblast growth factor (FGF) signaling has been implicated in the regulation of osteogenesis in both intramembranous and endochondral ossifications. In the developing palate, the anterior bony palate forms by direct differentiation of cranial neural crest (CNC)-derived mesenchymal cells, but the signals that regulate the osteogenic cell fate in the developing palate remain unclear. In the present study, we investigated the potential role of FGF signaling in osteogenic fate determination of the palatal mesenchymal cells. We showed that locally activated FGF8 signaling in the anterior palate using a Shox2^Cre knock-in allele and an R26R^Fgf8 allele leads to a unique palatal defect: a complete loss of the palatine process of the maxilla as well as formation of ectopic ca

SUBMITTER: Xu J 

PROVIDER: S-EPMC5958370 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature