Prostaglandin E₂ receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses.

ABSTRACT: Although an inflammatory microenvironment is required for successful implantation, an inflammatory overreaction is one of the causes of unexplained recurrent pregnancy losses (uRPL). Prostaglandin E₂ (PGE₂) plays a pivotal role in regulating immune balance during early pregnancy, and it can stimulate inflammatory reactions via prostaglandin E₂ receptor 3 (EP3). However, the role of PGE₂ receptor signaling in the uRPL remains unknown. We aimed to investigate whether EP3 signaling is involved in the mechanism of uRPL. Via immunohistochemistry we could show that the expression of cyclooxygenase-2, EP3 and G protein alpha inhibitor 1 (G_i1) was enhanced in the decidua of the uRPL group in comparison to the control group in first-trimester p

SUBMITTER: Ye Y 

PROVIDER: S-EPMC5958745 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature