Transfer of multiple loci of donor's genes to induce recipient tolerance in organ transplantation.

ABSTRACT: Donor organ rejection remains a significant problem. The present study aimed to assess whether transferring a donor's major histocompatibility complex (MHC) genes to the recipient could mitigate rejection in organ transplantation. Seven loci of MHC genes from donor mice were amplified and ligated into vectors; the vectors either contained one K locus, seven loci or were empty (control). The vectors were subsequently injected into the thymus of recipients (in heterotransplants, recipient rats received the vector containing one K locus), following which donor mouse hearts were transplanted. Following the transplantation of allograft and heterograft, electrocardiosignals were viable for a significantly longer duration in recipient mice and rats receiving the donor histocompatibility-2 complex

SUBMITTER: Li T 

PROVIDER: S-EPMC5958787 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature