The lncRNA myocardial infarction associated transcript-centric competing endogenous RNA network in non-small-cell lung cancer.

ABSTRACT:

Background

The leading cause of death for cancer is lung cancer, of which the majority subtype is non-small cell lung cancer (NSCLC). Recent studies have shown long non-coding RNAs are transcribed and contribute to cancer. Previous study has shown that a few single nucleotide polymorphisms (SNPs) in myocardial infarction associated transcript (MIAT) were associated with some diseases or function as competing endogenous RNA (ceRNA) in some cancer.

Patients and methods

We performed bioinformatic methods for analyzing RNA-seq and miRNA-seq data of NSCLC from The Cancer Genome Atlas database. 1352 NSCLC patients and 1320 cancer-free controls for genotyping, and dual luciferase reporter assay, real-time PCR are performed in A549 and H1975 lung cancer cell lines. Results are analy

SUBMITTER: Zheng C 

PROVIDER: S-EPMC5958945 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature