Castration induces satellite cell activation that contributes to skeletal muscle maintenance.

ABSTRACT:

Background

Sarcopenia, the age-related loss of skeletal muscle, is a side effect of androgen deprivation therapy (ADT) for prostate cancer patients. Resident stem cells of skeletal muscle, satellite cells (SCs), are an essential source of progenitors for the growth and regeneration of skeletal muscle. Decreased androgen signaling and deficits in the number and function of SCs are features of aging. Although androgen signaling is known to regulate skeletal muscle, the cellular basis for ADT-induced exacerbation of sarcopenia is unknown. Furthermore, the consequences of androgen deprivation on SC fate in adult skeletal muscle remain largely unexplored.

Methods

We examined SC fate in an androgen-deprived environment using immunofluorescence and fluorescence-activated cell sorti

SUBMITTER: Klose A 

PROVIDER: S-EPMC5959044 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature