MicroRNA duplication accelerates the recruitment of new targets during vertebrate evolution.

ABSTRACT: The repertoire of miRNAs has considerably expanded during metazoan evolution, and duplication is an important mechanism for generating new functional miRNAs. However, relatively little is known about the functional divergence between paralogous miRNAs and the possible coevolution between duplicated miRNAs and the genomic contexts. By systematically examining small RNA expression profiles across various human tissues and interrogating the publicly available miRNA:mRNA pairing chimeras, we found that changes in expression patterns and targeting preferences are widespread for duplicated miRNAs in vertebrates. Both the empirical interactions and target predictions suggest that evolutionarily conserved homo-seed duplicated miRNAs pair with significantly higher numbers of target sites compared t

SUBMITTER: Luo J 

PROVIDER: S-EPMC5959248 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature