Transmission of microRNA antimiRs to mouse offspring via the maternal-placental-fetal unit.

ABSTRACT: The emergence of microRNA as regulators of organogenesis and tissue differentiation has stimulated interest in the ablation of microRNA expression and function during discrete periods of development. To this end, inducible, conditional modulation of microRNA expression with doxycycline-based tetracycline-controlled transactivator and tamoxifen-based estrogen receptor systems has found widespread use. However, the induction agents and components of genome recombination systems negatively impact pregnancy, parturition, and postnatal development; thereby limiting the use of these technologies between late gestation and the early postnatal period. MicroRNA inhibitor (antimiR) administration also represents a means of neutralizing microRNA function in vitro and in vivo. To date, these studies h

SUBMITTER: Honig J 

PROVIDER: S-EPMC5959254 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature