Project description:Accuracy of sepsis prediction was obtained using cross-validation of gene expression data from 12 human spleen samples and from 16 mouse spleen samples. For blood studies, classifiers were constructed using data from a training data set of 26 microarrays. The error rate of the classifiers was estimated on seven de-identified microarrays, and then on a subsequent cross-validation for all 33 blood microarrays. Estimates of classification accuracy of sepsis in human spleen were 67.1%; in mouse spleen, 96%; and in mouse blood, 94.4% (all estimates were based on nested cross-validation). Lists of genes with substantial changes in expression between study and control groups were used to identify nine mouse common inflammatory response genes, six of which were mapped into a single pathway using contemporary pathway analysis tools. Keywords: genomics, diagnosis, microarray, calprotectin

2006-08-29 | GSE5663 | GEO

Amuvatinib has cytotoxic effects against NRAS-mutant melanoma but not BRAF-mutant melanoma.

Project description: Not available

| S-EPMC4384823 | biostudies-literature

Searching for the Chokehold of NRAS Mutant Melanoma.

Project description: Not available

| S-EPMC4921268 | biostudies-literature

NRAS mutant melanoma: an overview for the clinician for melanoma management.

Project description: Not available

| S-EPMC6097550 | biostudies-literature

Significance of BRAF Kinase Inhibitors for Melanoma Treatment: From Bench to Bedside.

Project description: Not available