Computer-guided design of optimal microbial consortia for immune system modulation.

ABSTRACT: Manipulation of the gut microbiota holds great promise for the treatment of diseases. However, a major challenge is the identification of therapeutically potent microbial consortia that colonize the host effectively while maximizing immunologic outcome. Here, we propose a novel workflow to select optimal immune-inducing consortia from microbiome compositicon and immune effectors measurements. Using published and newly generated microbial and regulatory T-cell (T_reg) data from germ-free mice, we estimate the contributions of twelve Clostridia strains with known immune-modulating effect to T_reg induction. Combining this with a longitudinal data-constrained ecological model, we predict the ability of every attainable and ecologically stable subconsortium in promoting T

SUBMITTER: Stein RR 

PROVIDER: S-EPMC5959721 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature