Biological correlates of self-reported new and continued abstinence in cannabis cessation treatment clinical trials.

ABSTRACT:

Background

The agreement between self-reported cannabis abstinence with urine cannabinoid concentrations in a clinical trials setting is not well characterized. We assessed the agreement between various cannabinoid cutoffs and self-reported abstinence across three clinical trials, one including contingency management for abstinence.

Methods

Three cannabis cessation clinical trials where participants reported use and provided weekly urine samples for cannabis and creatinine concentration measurements were included. Bootstrapped data were assessed for agreement between self-reported 7+ day abstinence and urine cannabinoid tests using generalized linear mixed effects models for clustered binary outcomes. One study implemented contingency management for cannabis abstinence. Four

SUBMITTER: Baker NL 

PROVIDER: S-EPMC5959795 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature