Higher 5-HT_1A autoreceptor binding as an endophenotype for major depressive disorder identified in high risk offspring - A pilot study.

ABSTRACT: Higher serotonin-1A (5-HT_1A) receptor binding potential (BP_F) has been found in major depressive disorder (MDD) during and between major depressive episodes. We investigated whether higher 5-HT_1A binding is a biologic trait transmitted to healthy high risk (HR) offspring of MDD probands. Data were collected contemporaneously from: nine HR, 30 depressed not-recently medicated (NRM) MDD, 18 remitted NRM MDD, 51 healthy volunteer (HV) subjects. Subjects underwent positron emission tomography (PET) using [¹¹C]WAY100635 to quantify 5-HT_1A BP_F, estimated using metabolite, free fraction-corrected arterial input function and cerebellar white matter as reference region. Multivoxel pattern analyses (MVPA) of PET data evaluated group s

SUBMITTER: Milak MS 

PROVIDER: S-EPMC5959803 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature