A logic-based method to build signaling networks and propose experimental plans.

ABSTRACT: With the dramatic increase of the diversity and the sheer quantity of biological data generated, the construction of comprehensive signaling networks that include precise mechanisms cannot be carried out manually anymore. In this context, we propose a logic-based method that allows building large signaling networks automatically. Our method is based on a set of expert rules that make explicit the reasoning made by biologists when interpreting experimental results coming from a wide variety of experiment types. These rules allow formulating all the conclusions that can be inferred from a set of experimental results, and thus building all the possible networks that explain these results. Moreover, given an hypothesis, our system proposes experimental plans to carry out in order to validate o

SUBMITTER: Rougny A 

PROVIDER: S-EPMC5959848 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature