Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection.

ABSTRACT: Non-typhoidal Salmonella strains are responsible for invasive infections associated with high mortality and recurrence in sub-Saharan Africa, and there is strong evidence for clonal relapse following antibiotic treatment. Persisters are non-growing bacteria that are thought to be responsible for the recalcitrance of many infections to antibiotics. Toxin-antitoxin systems are stress-responsive elements that are important for Salmonella persister formation, specifically during infection. Here, we report the analysis of persister formation of clinical invasive strains of Salmonella Typhimurium and Enteritidis in human primary macrophages. We show that all the invasive clinical isolates of both serovars that we tested produce high levels of persisters following internalization by human macroph

SUBMITTER: Rycroft JA 

PROVIDER: S-EPMC5959882 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature