Immune system correlates of extensive limb swelling in response to conjugated pneumococcal vaccination.

ABSTRACT: Pneumococcal conjugate vaccine (PCV) is recommended for adults with chronic disease. Extensive limb swelling (ELS) is an acute vigorous local inflammatory reaction following vaccination. Predisposing immune system correlates and the influence of ELS on vaccine responses are not known. Here, we report a case of a 67-year-old woman with a history of multiple pneumonias who had a detailed immunological work-up pre-vaccination because of suspected immunodeficiency. Four days following a first vaccination with PCV13 she developed ELS-mimicking erysipelas. Treatment with 20 mg cortisone completely alleviated symptoms within 2 days. Skin biopsy showed a dense dermal and subdermal infiltration dominated by CD4⁺ T cells and macrophages. In a multiplexed serotype-specific measurement of t

SUBMITTER: Recher M 

PROVIDER: S-EPMC5959910 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature