Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis.

ABSTRACT:

Background

Chemerin, a known chemoattractant, participates in multiple biological events. However, its role in cancer remains largely unknown.

Methods

Chemerin expression was evaluated by real-time PCR, western blot and immunohistochemistry. Forced expression, RNAi, immunoprecipitation, etc. were used in function and mechanism study. Mouse models of extrahepatic and intrahepatic metastasis were employed to evaluate the therapeutic potential of chemerin.

Results

Chemerin expression was significantly downregulated in hepatocellular carcinoma, and associated with poor prognosis of HCC patients. Forced expression of chemerin inhibited in vitro migration, invasion and in vivo metastasis of HCC cells. Administration of chemerin effectively suppressed extrahepatic and intrah

SUBMITTER: Li JJ 

PROVIDER: S-EPMC5959946 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature