Cross-sectional networks of depressive symptoms before and after antidepressant medication treatment.

ABSTRACT:

Purpose

Recent reviews have questioned the efficacy of selective serotonin reuptake inhibitors (SSRIs) above placebo response, and their working mechanisms remain unclear. New approaches to understanding the effects of SSRIs are necessary to enhance their efficacy. The aim of this study was to explore the possibilities of using cross-sectional network analysis to increase our understanding of symptom connectivity before and after SSRI treatment.

Methods

In two randomized controlled trials (total N = 178), we estimated Gaussian graphical models among 20 symptoms of the Beck Depression Inventory-II before and after 8 weeks of treatment with the SSRI paroxetine. Networks were compared on connectivity, community structure, predictability (proportion explained variance), and stre

SUBMITTER: Bos FM 

PROVIDER: S-EPMC5959987 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature