Association of AIRE Polymorphism and the Susceptibility to Multiple Sclerosis in Iranian Population.

ABSTRACT:

Background

Multiple Sclerosis (MS) is the most common cause of neurologic disability in young adults. Recently, the AIRE gene was identified as a genetic risk factor for several autoimmune diseases in genome wide association studies. The aim of this study was to further investigate the possible role of the AIRE gene in susceptibility to MS in Iranian population.

Methods

A total of 112 MS patients and 94 ethnically matched controls were included in the study. The Single-Nucleotide Polymorphism (SNP) (rs1800520, C>G) with a global MAF=0.2282/1143 was selected and genotyped using HRM real-time PCR method.

Results

Results showed that AIRE SNP rs1800520 was significantly less common in the MS patients than in healthy controls (17.8 vs. 28.7%, pc

SUBMITTER: Sadeghian-Rizi T 

PROVIDER: S-EPMC5960056 | biostudies-literature | 2018 Apr-Jun

REPOSITORIES: biostudies-literature