Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.

ABSTRACT: BACKGROUND:Systemic inflammation induces neuroinflammation and cellular changes such as tau phosphorylation to impair cognitive function, including learning and memory. This study uses a single model, laparotomy without any pathogen, to characterize these changes and their responses to anti-inflammatory treatment in the intermediate term. METHODS:In a two-part experiment, wild-type C57BL/6N mice (male, 3 month old, 25 ± 2 g) were subjected to sevoflurane anesthesia alone or to a laparotomy. Cognitive performance, systemic and neuroinflammatory responses, and tau phosphorylation were evaluated on postoperative days (POD) 1, 3, and 14. The effect of perioperative ibuprofen intervention (60 mg/kg) on these changes was then assessed. RESULTS:Mice in the laparotomy group displayed memory impair

SUBMITTER: Huang C 

PROVIDER: S-EPMC5960121 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature