Different adaptive strategies in E. coli populations evolving under macronutrient limitation and metal ion limitation.

ABSTRACT:

Background

Adaptive responses to nutrient limitation involve mutations that increase the efficiency of usage or uptake of the limiting nutrient. However, starvation of different nutrients has contrasting effects on physiology, resulting in different evolutionary responses. Most studies performed to understand these evolutionary responses have focused only on macronutrient limitation. Hence our understanding of adaptation under limitation of other forms of nutrients is limited. In this study, we compared the evolutionary response in populations evolving under growth-limiting conditions for a macronutrient and a major cation.

Results

We evolved eight populations of E. coli in nutrient-limited chemostats for 400 generations to identify the genetic basis of the mechanisms involv

SUBMITTER: Warsi OM 

PROVIDER: S-EPMC5960147 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature