Competence of mosquitoes native to the United Kingdom to support replication and transmission of Rift Valley fever virus.

ABSTRACT:

Background

Rift Valley fever phlebovirus (RVFV) is a mosquito-borne arbovirus causing severe disease in humans and livestock. It is endemic in Africa and spread to the Arabian Peninsula in 2000 raising concerns it could emerge in Europe. The ability of temperate mosquitoes from the United Kingdom (UK) to support replication and transmission of RVFV is unknown.

Methods

In this study, two colonised lines of Culex pipiens, wild-caught Aedes detritus and Ae. rusticus from the UK were infected with pathogenic strains of RVFV to assess their vector competence. Mosquitoes were offered artificial blood-meals containing 10⁶ or 10⁷ plaque forming units (PFU)/ml RVFV, simulating natural peak viraemia in young ruminants, and maintained at 20 °C or 25 °C for up to 2

SUBMITTER: Lumley S 

PROVIDER: S-EPMC5960175 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature