The association between rs12901499 polymorphism in SMAD3 gene and risk of osteoarthritis: a meta-analysis.

ABSTRACT:

Purpose

This study was conducted to assess and synthesize the current evidence on the association between rs12901499 polymorphism in SMAD3 gene and risk of osteoarthritis (OA).

Materials and methods

Four electronic databases, including PubMed, Embase, ISI Web of Science, and CENTRAL were systematically searched for potential studies. Summary odds ratio and corresponding 95% CI were calculated to evaluate the association. Risk of bias was assessed through the Newcastle-Ottawa Scale. Subgroups and sensitivity analyses were performed using the RevMan 5.3 software. Publication bias was evaluated by Egger's and Begg's tests. Power analysis was conducted using the Power and Sample Size Calculation program.

Results

Eight case-control studies containing 5,625 patients with OA

SUBMITTER: Gao ST 

PROVIDER: S-EPMC5960251 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature