Ligand metathesis as rational strategy for the synthesis of cubane-type heteroleptic iron-sulfur clusters relevant to the FeMo cofactor.

ABSTRACT: Molybdenum-dependent nitrogenases catalyze the transformation of dinitrogen into ammonia under ambient conditions. The active site (FeMo cofactor) is the structurally and electronically complex weak-field metal cluster [MoFe₇S₉C] built of Fe₄S₃ and MoFe₃S₃C portions connected by three sulfur bridges and containing an interstitial carbon atom centered in an Fe₆ trigonal prism. Chemical synthesis of this cluster is a major challenge in biomimetic inorganic chemistry. One synthetic approach of core ligand metathesis has been developed based on the design and synthesis of unprecedented incomplete ([(Tp*)WFe₂S₃Q₃]^-) and complete ([(Tp*)WFe₃S₃Q₄

SUBMITTER: Xu G 

PROVIDER: S-EPMC5960317 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature