Circulating bile acids in healthy adults respond differently to a dietary pattern characterized by whole grains, legumes and fruits and vegetables compared to a diet high in refined grains and added sugars: A randomized, controlled, crossover feeding study.

ABSTRACT:

Objective

The effects of diets high in refined grains on biliary and colonic bile acids have been investigated extensively. However, the effects of diets high in whole versus refined grains on circulating bile acids, which can influence glucose homeostasis and inflammation through activation of farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5), have not been studied.

Materials and methods

We conducted a secondary analysis from a randomized controlled crossover feeding trial (NCT00622661) in 80 healthy adults (40 women/40 men, age 18-45 years) from the greater Seattle Area, half of which were normal weight (BMI 18.5-25.0 kg/m²) and half overweight to obese (BMI 28.0-39.9 kg/m²). Participants consumed two four-week controlled di

SUBMITTER: Ginos BNR 

PROVIDER: S-EPMC5960615 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature