Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer.

ABSTRACT:

Background

Proton pencil beam (PB) dose calculation algorithms have limited accuracy within heterogeneous tissues of lung cancer patients, which may be addressed by modern commercial Monte Carlo (MC) algorithms. We investigated clinical pencil beam scanning (PBS) dose differences between PB and MC-based treatment planning for lung cancer patients.

Methods

With IRB approval, a comparative dosimetric analysis between RayStation MC and PB dose engines was performed on ten patient plans. PBS gantry plans were generated using single-field optimization technique to maintain target coverage under range and setup uncertainties. Dose differences between PB-optimized (PBopt), MC-recalculated (MCrecalc), and MC-optimized (MCopt) plans were recorded for the following region-of-interest

SUBMITTER: Maes D 

PROVIDER: S-EPMC5960654 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature