Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 In Acute Apical Abscess.

ABSTRACT:

Statement of the problem

Genetic polymorphisms can alter immunity response against pathogens, which in turn influence individuals' susceptibility to certain infections.

Purpose

Our aim was to determine the association of Arg753Gln (rs5743708) and Arg677Trp (rs12191786) polymorphisms of toll like receptor-2 gene with the two clinical forms of apical periodontitis: acute apical abscess (AAA) and asymptomatic apical periodontitis (AAP).

Materials and method

There were 50 patients with AAA as case group and 50 with AAP as control group. Genotyping was done using Tetra-ARMS (amplification refractory mutation system) PCR.

Results

Heterozygous genotype of Arg677Trp polymorphism was associated with risk of AAA (OR=1.9, 95% CI: 0.7-5.5, p= 0.05). Although statist

SUBMITTER: Miri-Moghaddam E 

PROVIDER: S-EPMC5960730 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature