PTH Gene Polymorphism and Breast Cancer Risk in Kazakhstan.

ABSTRACT:

Introduction

Breast cancer is the most common type of cancer among women. In Kazakhstan, breast cancer holds first place among causes of women death caused by cancer in the 45-55 year age group. Many studies have shown that the risk of acquiring breast cancer may be related to the level of calcium in the blood serum. One of the important regulators of calcium metabolism in the body is the parathyroid hormone. Single nucleotide polymorphisms in the gene encoding the parathyroid hormone (PTH) are associated with breast cancer development risk, and may modify the associative interaction between the levels of calcium intake and breast cancer. Experimental studies have shown that PTH gene has a carcinogenic effect. At least three studies showed a weak positive correlation between the ri

SUBMITTER: Sikhayeva N 

PROVIDER: S-EPMC5960943 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature