Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism.

ABSTRACT: Compartmentalization is a fundamental design principle of eukaryotic metabolism. Here, we review the compartmentalization of NAD⁺/NADH and NADP⁺/NADPH with a focus on the liver, an organ that experiences the extremes of biochemical physiology each day. Historical studies of the liver, using classical biochemical fractionation and measurements of redox-coupled metabolites, have given rise to the prevailing view that mitochondrial NAD(H) pools tend to be oxidized and important for energy homeostasis, whereas cytosolic NADP(H) pools tend to be highly reduced for reductive biosynthesis. Despite this textbook view, many questions still remain as to the relative size of these subcellular pools and their redox ratios in different physiological states, and to what extent such

SUBMITTER: Goodman RP 

PROVIDER: S-EPMC5961030 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature