The cell division protein MinD from Pseudomonas aeruginosa dominates the assembly of the MinC-MinD copolymers.

ABSTRACT: Cell division of rod-shaped bacteria requires the Z ring, a ring of FtsZ filaments associated with the inner-membrane wall. The MinCDE proteins help localize the Z ring to the center of the Escherichia coli cell. MinC, which inhibits Z-ring assembly, is a passenger on MinD. Previous studies have shown that MinC-MinD from E. coli and Aquifex aeolicus assemble in vitro into extended filaments with a 1:1 stoichiometry. However, a recent study has raised questions about the function of the MinC-MinD copolymer in vivo, because its assembly appears to require a high concentration of these two proteins and has a long lag time, and its blockade does not affect in vivo activities. Here, we found that MinC and MinD from Pseudomonas aeruginosa coassemb

SUBMITTER: Huang H 

PROVIDER: S-EPMC5961031 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature