Cyclase-associated protein 1 (CAP1) is a prenyl-binding partner of Rap1 GTPase.

ABSTRACT: Rap1 proteins are members of the Ras subfamily of small GTPases involved in many biological responses, including adhesion, cell proliferation, and differentiation. Like all small GTPases, they work as molecular allosteric units that are active in signaling only when associated with the proper membrane compartment. Prenylation, occurring in the cytosol, is an enzymatic posttranslational event that anchors small GTPases at the membrane, and prenyl-binding proteins are needed to mask the cytoplasm-exposed lipid during transit to the target membrane. However, several of these proteins still await discovery. In this study, we report that cyclase-associated protein 1 (CAP1) binds Rap1. We found that this binding is GTP-independent, does not involve Rap1's effector domain, and is fully contained

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5961064 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature