Duration of exposure to multiple antibiotics is associated with increased risk of VRE bacteraemia: a nested case-control study.

ABSTRACT:

Background

VRE bacteraemia has a high mortality and continues to defy control. Antibiotic risk factors for VRE bacteraemia have not been adequately defined. We aimed to determine the risk factors for VRE bacteraemia focusing on duration of antibiotic exposure.

Methods

A retrospective matched nested case-control study was conducted amongst hospitalized patients at Cambridge University Hospitals NHS Foundation Trust (CUH) from 1 January 2006 to 31 December 2012. Cases who developed a first episode of VRE bacteraemia were matched 1:1 to controls by length of stay, year, specialty and ward type. Independent risk factors for VRE bacteraemia were evaluated using conditional logistic regression.

Results

Two hundred and thirty-five cases were compared with 220 controls. Durat

SUBMITTER: Gouliouris T 

PROVIDER: S-EPMC5961253 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature