G-Anchor: a novel approach for whole-genome comparative mapping utilizing evolutionary conserved DNA sequences.

ABSTRACT:

Background

Cross-species whole-genome sequence alignment is a critical first step for genome comparative analyses, ranging from the detection of sequence variants to studies of chromosome evolution. Animal genomes are large and complex, and whole-genome alignment is a computationally intense process, requiring expensive high-performance computing systems due to the need to explore extensive local alignments. With hundreds of sequenced animal genomes available from multiple projects, there is an increasing demand for genome comparative analyses.

Results

Here, we introduce G-Anchor, a new, fast, and efficient pipeline that uses a strictly limited but highly effective set of local sequence alignments to anchor (or map) an animal genome to another species' reference genome. G-An

SUBMITTER: Lenis VPE 

PROVIDER: S-EPMC5961299 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature