Transferable vancomycin resistance in clade B commensal-type Enterococcus faecium.

ABSTRACT:

Objectives

Vancomycin-resistant Enterococcus faecium is a leading cause of MDR hospital infection. Two genetically definable populations of E. faecium have been identified: hospital-adapted MDR isolates (clade A) and vancomycin-susceptible commensal strains (clade B). VanN-type vancomycin resistance was identified in two isolates of E. faecium recovered from blood and faeces of an immunocompromised patient. To understand the genomic context in which VanN occurred in the hospitalized patient, the risk it posed for transmission in the hospital and its origins, it was of interest to determine where these strains placed within the E. faecium population structure.

Methods

We obtained the genome sequence of the VanN isolates and performed comparative and functional genomics of the

SUBMITTER: Lebreton F 

PROVIDER: S-EPMC5961315 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature