Functional variants of TIM-3/HAVCR2 3'UTR in lymphoblastoid cell lines.

ABSTRACT:

Aim

Variants of TIM-3/HAVCR2 3'UTR miRNA binding sites are significantly associated with cancer; however, roles in post-transcriptional regulation have not been elucidated.

Methods

The regulatory and coding region single nucleotide polymorphisms (SNPs) of TIM-3/HAVCR2 were identified using an online database. Single nucleotide polymorphism Function Prediction was used to predict potential functional relevance of miRNA binding sites.

Results

The analysis indicated rs9313439, rs4704846, rs3087616 and rs1036199 affect possible miRNA binding sites in TIM-3/HAVCR2 3'UTR. We used additional data on genotypes and limited minor allele frequency >5% in the HapMap populations. Only rs3087616 and rs4704846 were significantly associated with TIM-3/HAVCR2</

SUBMITTER: Pu F 

PROVIDER: S-EPMC5961449 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature