Genomic insights into nitrofurantoin resistance mechanisms and epidemiology in clinical Enterobacteriaceae.

ABSTRACT:

Aim

Multidrug-resistant enterobacteria are highly associated with invasive devices and intensive care units. Increasing resistance to carbapenems is leading to the use of older and neglected antibiotics such as nitrofurantoin (NFT). The genomics of NFT resistance was investigated.

Results & conclusion

High-level resistance to NFT (minimum inhibitory concentration ≥128-512 mg/l) was recorded in 31/36 isolates (89.6%), many of which were from intensive care units (n = 20), urine (n = 17) or invasive procedures (n = 10). Efflux pump inhibitors had little effect on NFT's minimum inhibitory concentrations albeit oqxAB was prevalent in most isolates (n = 32). Various species- and clone-specific mutations mediating high-level NFT resistance were detected in nfsA, nfsB and ri

SUBMITTER: Osei Sekyere J 

PROVIDER: S-EPMC5961450 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature