Involvement of RNA helicase p68 in skin wound healing process in rats.

ABSTRACT:

Purpose

RNA helicase p68 plays an important role in organ development and maturation through tuning cell proliferation. However, the character and role of p68 in the whole wound healing process need more study.

Methods

First, we characterize expression of p68 in normal rat skin development postnatal. Then, we assayed dynamic change of p68 in rat skin from different stage after injury, and explored the role of p68 in proliferation and migration of three types of wound healing related cells.

Results

p68 was down-regulated during skin developmental and maturation process, up-regulated after wound, peaked on day 14 and then significantly decreased. Wound fluid enhanced wound healing related cell proliferation and up-regulated expression of p68. Conversely, reducing p68 ex

SUBMITTER: Wang SJ 

PROVIDER: S-EPMC5961762 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature