Attenuation and efficacy of live-attenuated Rift Valley fever virus vaccine candidates in non-human primates.

ABSTRACT: Rift Valley fever virus (RVFV) is an important mosquito-borne veterinary and human pathogen that has caused large outbreaks of severe disease throughout Africa and the Arabian Peninsula. Currently, no licensed vaccine or therapeutics exists to treat this potentially deadly disease. The explosive nature of RVFV outbreaks and the severe consequences of its accidental or intentional introduction into RVFV-free areas provide the impetus for the development of novel vaccine candidates for use in both livestock and humans. Rationally designed vaccine candidates using reverse genetics have been used to develop deletion mutants of two known RVFV virulence factors, the NSs and NSm genes. These recombinant viruses were demonstrated to be protective and immunogenic in rats, mice, and sheep, without p

SUBMITTER: Smith DR 

PROVIDER: S-EPMC5962102 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature