Ontology highlight
ABSTRACT:
SUBMITTER: Hicks MR
PROVIDER: S-EPMC5962356 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Hicks Michael R MR Hiserodt Julia J Paras Katrina K Fujiwara Wakana W Eskin Ascia A Jan Majib M Xi Haibin H Young Courtney S CS Evseenko Denis D Nelson Stanley F SF Spencer Melissa J MJ Handel Ben Van BV Pyle April D AD
Nature cell biology 20171218 1
Human pluripotent stem cells (hPSCs) can be directed to differentiate into skeletal muscle progenitor cells (SMPCs). However, the myogenicity of hPSC-SMPCs relative to human fetal or adult satellite cells remains unclear. We observed that hPSC-SMPCs derived by directed differentiation are less functional in vitro and in vivo compared to human satellite cells. Using RNA sequencing, we found that the cell surface receptors ERBB3 and NGFR demarcate myogenic populations, including PAX7 progenitors i ...[more]